Common limits for therapeutic application of peptides and proteins are their chemical instability, their short residence time in blood and their tendency to promote an immunological response. Most of these problems may be solved by linking one or more PEG (polyethylene glycol) molecules to these peptides and proteins (PEGylation). This is achieved due to the combination of increased molecular weight and coverage of epitopes or blockage of sequences prone to enzymatic degradation. In addition, PEGylation enhances protein solubility in aqueous solutions.

Currently available PEGylation technologies produce products which are PEGylated at multiple sites in an uncontrolled manner. This inevitably results in a population of molecules PEGylated in locations which crowd the active centre or binding regions resulting in a net decrease in potency versus the un-PEGylated analogue.

Creative BioMart's chemists will perform your PEGylation service in a professional and efficient way to provide you the PEGylated products in very short period of time and with high quality.

PEG-CtrlTM is a novel site-selective PEGylation platform, using a proprietary efficient and cost-effective PEGylation chemistry, which is suitable to a large variety of proteins.

The PEG-CtrlTM unique approach enables homogeneous PEGylated populations where the specific PEGylation site can be selected and controlled, thus improving efficacy compared to existing PEGylation techniques, decreasing cost of goods and substance dosed to patient; while still providing an improved ADME profile due to the addition of the PEG moiety.

Srevice Items：

1 PEGylation service as a regular customer product

Creativebiomart PEG-CtrlTM Service provides you an economic approache to initial evaluation of your PEGylation approach. This service will PEGylate your molecular and deliver your PEGylated product with a certificate of analysis.

2 Complete PEGylation method development service

Under this service model, we will provide your PEGylated sample as well as the complete PEGylation method development package. The PEGylation process Creative BioMart developed for you will be easily scalable and easily transferable with all the necessary analytical methods developed in the same time.

Welcome to contact us or send an email to info@creative-biomart.com for project quotations and more detailed information.

http://www.creativebiomart.net/pegylation-services.htm