Membrane proteins such as receptors and ion channels are key regulators of cellular function. Membrane proteins account for up to two thirds of known drugable targets, highlighting their critical pharmaceutical importance. 

One of the largest, most versatile group of membrane receptors, the G protein-coupled receptors (GPCRs), is also the most pharmaceutically important, accounting for over 50% of all human drug targets and acting as therapeutic targets for a wide range of disease conditions including cancer, cardiovascular, metabolic, CNS and inflammatory diseases. 

Ion channels represent another group of important membrane protein drug targets and account for the activity of 10% of the currently marketed drugs.

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